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mitogen activated protein kinase mek 1 2  (MedChemExpress)


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    MedChemExpress mitogen activated protein kinase mek 1 2
    Mitogen Activated Protein Kinase Mek 1 2, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 98/100, based on 537 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/mitogen+activated+protein+kinase+1+2/PD98059/pmc12651841-33-4-12
    Average 98 stars, based on 537 article reviews
    mitogen activated protein kinase mek 1 2 - by Bioz Stars, 2026-10
    98/100 stars

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    Related Articles

    Expressing:

    Article Title: Activation of MEK1/2/Nrf-2 Signaling Pathway by Epstein-Barr Virus-Latent Membrane Protein 1 Enhances Autophagy and Cisplatin Resistance in T-Cell Lymphoma
    Article Snippet: .. The SNK-6 cells in good growth condition with stable low expression of LMP1 were cultured with the autophagy activator rapamycin (0.5 nM, ab120224, Abcam, Cambridge, UK), nuclear factor-erythroid 2-related factor 2- (Nrf-2-) specific activator cheirolin (10 ng/mL, ab142855, Abcam), or the control dimethylsulfoxide (DMSO) for 12 h. The KHYG-1 cells in good growth condition with stable overexpression of LMP1 were treated with autophagy inhibitor 3-MA (5 mM, HY-19312, MedChemExpress, Monmouth Junction, NJ, USA), Mitogen-activated protein kinase 1/2- (MEK1/2-) specific inhibitor SL327 (20 ng/mL, #HY-15437, MedChemExpress), or the control DMSO for 24 h. The cells were collected for subsequent experiments. ..

    Cell Culture:

    Article Title: Activation of MEK1/2/Nrf-2 Signaling Pathway by Epstein-Barr Virus-Latent Membrane Protein 1 Enhances Autophagy and Cisplatin Resistance in T-Cell Lymphoma
    Article Snippet: .. The SNK-6 cells in good growth condition with stable low expression of LMP1 were cultured with the autophagy activator rapamycin (0.5 nM, ab120224, Abcam, Cambridge, UK), nuclear factor-erythroid 2-related factor 2- (Nrf-2-) specific activator cheirolin (10 ng/mL, ab142855, Abcam), or the control dimethylsulfoxide (DMSO) for 12 h. The KHYG-1 cells in good growth condition with stable overexpression of LMP1 were treated with autophagy inhibitor 3-MA (5 mM, HY-19312, MedChemExpress, Monmouth Junction, NJ, USA), Mitogen-activated protein kinase 1/2- (MEK1/2-) specific inhibitor SL327 (20 ng/mL, #HY-15437, MedChemExpress), or the control DMSO for 24 h. The cells were collected for subsequent experiments. ..

    Control:

    Article Title: Activation of MEK1/2/Nrf-2 Signaling Pathway by Epstein-Barr Virus-Latent Membrane Protein 1 Enhances Autophagy and Cisplatin Resistance in T-Cell Lymphoma
    Article Snippet: .. The SNK-6 cells in good growth condition with stable low expression of LMP1 were cultured with the autophagy activator rapamycin (0.5 nM, ab120224, Abcam, Cambridge, UK), nuclear factor-erythroid 2-related factor 2- (Nrf-2-) specific activator cheirolin (10 ng/mL, ab142855, Abcam), or the control dimethylsulfoxide (DMSO) for 12 h. The KHYG-1 cells in good growth condition with stable overexpression of LMP1 were treated with autophagy inhibitor 3-MA (5 mM, HY-19312, MedChemExpress, Monmouth Junction, NJ, USA), Mitogen-activated protein kinase 1/2- (MEK1/2-) specific inhibitor SL327 (20 ng/mL, #HY-15437, MedChemExpress), or the control DMSO for 24 h. The cells were collected for subsequent experiments. ..

    Over Expression:

    Article Title: Activation of MEK1/2/Nrf-2 Signaling Pathway by Epstein-Barr Virus-Latent Membrane Protein 1 Enhances Autophagy and Cisplatin Resistance in T-Cell Lymphoma
    Article Snippet: .. The SNK-6 cells in good growth condition with stable low expression of LMP1 were cultured with the autophagy activator rapamycin (0.5 nM, ab120224, Abcam, Cambridge, UK), nuclear factor-erythroid 2-related factor 2- (Nrf-2-) specific activator cheirolin (10 ng/mL, ab142855, Abcam), or the control dimethylsulfoxide (DMSO) for 12 h. The KHYG-1 cells in good growth condition with stable overexpression of LMP1 were treated with autophagy inhibitor 3-MA (5 mM, HY-19312, MedChemExpress, Monmouth Junction, NJ, USA), Mitogen-activated protein kinase 1/2- (MEK1/2-) specific inhibitor SL327 (20 ng/mL, #HY-15437, MedChemExpress), or the control DMSO for 24 h. The cells were collected for subsequent experiments. ..



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    Image Search Results


    Stimulation of NP cells with S. aureus and C. acnes combined with inhibitors. In cell‐ELISA was used to measure phospho‐ ERK, JNK, p38 and NFkB. Cells in monolayer under hypoxia were left to attach overnight before treatment with the inhibitors for TLR2, NODin1 and both combined for 24 h. Followed by the inhibition was treatment with 50 μg/mL PGN, S. aureus (MOI 0.01) and C. acnes (MOI 0.01) for 2 h in combination with the inhibitors. The different shades of blue represent the different donors ( N = 3 donors, n = 3 wells, (stats performed on n = 9)). All the measured concentrations were normalized to the non‐treated control. The No treatment graphs, show the different levels of phospho ERK, JNK, p38 and NFkB for cells only inhibited but not treated with a stimulant. No Inhibition shows treatment with PGN, S. aureus and C. acnes without inhibitors and TLR2, NODin1 and Combined Inhibition show the treatment combined with the inhibition. Statistical analysis was performed using Kruskal Wallis multiple comparison against the control group of each treatment ( p = 0.05).

    Journal: JOR Spine

    Article Title: Intracellular Detection of C. acnes and S. aureus in Non‐Herniated Human Intervertebral Discs: Implications for Catabolic Signaling Pathways

    doi: 10.1002/jsp2.70139

    Figure Lengend Snippet: Stimulation of NP cells with S. aureus and C. acnes combined with inhibitors. In cell‐ELISA was used to measure phospho‐ ERK, JNK, p38 and NFkB. Cells in monolayer under hypoxia were left to attach overnight before treatment with the inhibitors for TLR2, NODin1 and both combined for 24 h. Followed by the inhibition was treatment with 50 μg/mL PGN, S. aureus (MOI 0.01) and C. acnes (MOI 0.01) for 2 h in combination with the inhibitors. The different shades of blue represent the different donors ( N = 3 donors, n = 3 wells, (stats performed on n = 9)). All the measured concentrations were normalized to the non‐treated control. The No treatment graphs, show the different levels of phospho ERK, JNK, p38 and NFkB for cells only inhibited but not treated with a stimulant. No Inhibition shows treatment with PGN, S. aureus and C. acnes without inhibitors and TLR2, NODin1 and Combined Inhibition show the treatment combined with the inhibition. Statistical analysis was performed using Kruskal Wallis multiple comparison against the control group of each treatment ( p = 0.05).

    Article Snippet: Protein phosphorylation was measured for c‐Jun‐N‐terminal kinase (JNK, CBEL‐JNK‐1, RayBiotech, GA 30092, US) p38 mitogen‐activated protein kinase (p38, CBEL‐P38, RayBiotech), extracellular signal‐regulated kinase (ERK, CBEL‐ERK, RayBiotech) and nuclear factor kappa B p65 (NFkB, FBCAB0073, Assay Genie, Dublin Ireland) as per the manufacturer's instructions.

    Techniques: In-Cell ELISA, Inhibition, Control, Comparison